Vascular endothelial growth factor (VEGF) and Endocrine gland-VEGF (EG-VEGF) are down regulated in head and neck cancer.

Si Mohamed BouzoubaaMohammed BenlahfidMustapha SidquiTouria AboussaouiraChouaib RifkiSophie BrouilletWael TraboulsiNadia Alfaidy Mohamed Benharouga

Published in: Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery (2020)

We demonstrated that circulating VEGF and EG-VEGF are downregulated in HNC patients and in OSCC tissue. EG-VEGF receptors were increased in OSCC, along with a stabilisation of two key markers of angiogenesis. These findings strongly suggest that downregulation of angiogenesis in HNC might explain its moderate metastatic feature.

Keyphrases

vascular endothelial growth factor
endothelial cells
end stage renal disease
small cell lung cancer
newly diagnosed
ejection fraction
machine learning
cell proliferation
prognostic factors
peritoneal dialysis