The role of inflammation in the prospective associations between early childhood sleep problems and ADHD at 10 years: findings from a UK birth cohort study.

Isabel Morales-MunozRachel UpthegroveKate LawrenceRasiah ThayakaranSandra KooijAlice M GregorySteven Marwaha

Published in: Journal of child psychology and psychiatry, and allied disciplines (2023)

Several sleep problems in early childhood constitute a risk factor for probable ADHD diagnosis at 10 years. Further, these associations are partially mediated by IL-6 at 9 years. These results open a new research vista to the pathophysiology of ADHD and highlight sleep and inflammation as potential preventative targets for ADHD.

Keyphrases

attention deficit hyperactivity disorder
autism spectrum disorder
working memory
sleep quality
mental health
oxidative stress
physical activity
minimally invasive
climate change