Ling-Gui-Zhu-Gan Decoction Protects H9c2 Cells against H2O2-Induced Oxidative Injury via Regulation of the Nrf2/Keap1/HO-1 Signaling Pathway.

Xiang WangTongjuan TangMengting ZhaiRuirui GeLiang WangJin-Ling Huang Peng Zhou

Published in: Evidence-based complementary and alternative medicine : eCAM (2020)

Our results demonstrated that LGZGD attenuated the H2O2-induced injury to H9c2 cells by inhibiting oxidative stress and apoptosis via the Nrf2/Keap1/HO-1 pathway. These observations suggest that LGZGD might prevent and treat heart failure through regulation of the oxidative stress response.

Keyphrases

oxidative stress
induced apoptosis
cell cycle arrest
diabetic rats
signaling pathway
pi k akt
endoplasmic reticulum stress
heart failure
cell death
high glucose
dna damage
cell proliferation
drug induced
epithelial mesenchymal transition
protein protein
small molecule