Insulin-like growth factor 1 associated with altered immune responses in preterm infants and pigs.
Ole BækMartin Bo RasmussenTherese GertsLise AunsholtGitte ZachariassenPer SangildDuc Ninh NguyenPublished in: Pediatric research (2023)
Supplementation of insulin-like growth factor 1 (IGF-1) to preterm infants has been proposed to promote postnatal growth, but its impact on the developing immune system is largely unknown. In a cohort of very preterm infants, low gestational age and birth weight were the primary predictors of low plasma levels of IGF-1, which in turn were associated with plasma immune markers. Meanwhile, in immature preterm pigs, experimental supplementation of IGF-1 reduced Th1-related immune responses in early life. Supplementation of IGF-1 to preterm infants may affect the developing immune system, which needs consideration when evaluating overall impact on neonatal health.
Keyphrases
- preterm infants
- gestational age
- birth weight
- growth hormone
- low birth weight
- immune response
- preterm birth
- early life
- pi k akt
- binding protein
- weight gain
- healthcare
- public health
- toll like receptor
- mental health
- signaling pathway
- sensitive detection
- health information
- cell proliferation
- weight loss
- living cells
- quantum dots