Genetic deletion or pharmacologic inhibition of HDAC6 protects the heart against ischemia/reperfusion injury by limiting TNFα-induced mitochondrial injury in experimental diabetes.

Shelley L BaumgardtJuan FangXuebin FuYanan LiuZhengyuan XiaMing ZhaoLing ChenRachana MishraMuthukumar GunasekaranProgyaparamita SahaJoseph M ForbessZeljko J BosnjakAmadou Ks CamaraJudy R KerstenEdward B ThorpSunjay KaushalZhi-Dong Ge

Published in: Cardiovascular research (2024)

HDAC6 is an essential negative regulator of MIRI in diabetes. Genetic deletion or pharmacologic inhibition of HDAC6 protects the heart from MIRI by limiting TNFα-induced mitochondrial injury in experimental diabetes.

Keyphrases

type diabetes
oxidative stress
cardiovascular disease
diabetic rats
ischemia reperfusion injury
glycemic control
rheumatoid arthritis
high glucose
histone deacetylase
genome wide
atrial fibrillation
transcription factor
gene expression
endothelial cells
dna methylation
skeletal muscle
insulin resistance