Intrinsic Disorder in BAP1 and Its Association with Uveal Melanoma.

Mak B DjulbegovicDavid J TaylorVladimir N Uversky Anat GalorCarol L ShieldsCarol L Karp

Published in: Genes (2022)

These findings show that BAP1 contains IDPRs and an intricate PPI network. Mutations in UM that are associated with the BAP1 gene may alter the function of the IDPRs embedded into its structure. These findings develop the understanding of UM and may provide a target for potential novel therapies to treat this aggressive neoplasm.

Keyphrases

basal cell carcinoma
genome wide
copy number
low grade
protein protein
dna methylation
gene expression
human health
small molecule
network analysis