Association of DNA repair genes polymorphisms with childhood acute lymphoblastic leukemia: a high-resolution melting analysis.
Shahrzad ZehtabMahla Sattarzadeh BardsiriRoohollah Mirzaee KhalilabadiMohsen EhsanAhmad FatemiPublished in: BMC research notes (2022)
The prevalence of all three SNVs in XRCC1 and NBN genes did not differ between the patient and control groups, and these polymorphisms were not associated with childhood ALL risk (P > 0.05). HRM was a practical method for the detection of SNVs in XRCC1 and NBN genes. We found no significant association between XRCC1 (rs1799782) and NBN (rs1805794, rs709816) SNVs and childhood ALL risk.
Keyphrases
- dna repair
- high resolution
- dna damage
- acute lymphoblastic leukemia
- genome wide
- dna damage response
- bioinformatics analysis
- early life
- genome wide identification
- childhood cancer
- risk factors
- dna methylation
- genome wide analysis
- mass spectrometry
- gene expression
- young adults
- loop mediated isothermal amplification
- liquid chromatography
- sensitive detection