Immune hyporeactivity to bacteria and multiple TLR-ligands, yet no response to checkpoint inhibition in patients just after meeting Sepsis-3 criteria.

Alexandra BickWillem BuysAndrea EnglerRabea MadelMazen AtiaFrancesca FaroAstrid M WestendorfAndreas LimmerJan BuerFrank HerbstreitCarsten J KirschningJürgen Peters

Published in: PloS one (2022)

Patients first meeting Sepsis-3 criteria reveal 1) depressed responses to multiple TLR-ligands, bacteria, and bacterial LPS, despite concomitant inflammation, but 2) no response to immune checkpoint inhibition.

Keyphrases

end stage renal disease
ejection fraction
inflammatory response
chronic kidney disease
newly diagnosed
intensive care unit
immune response
peritoneal dialysis
prognostic factors
oxidative stress
dna damage
cell cycle
cell proliferation
patient reported
anti inflammatory