Kinetic Modelling and Test-Retest Reproducibility for the Dopamine D1R Radioligand [11C]SCH23390 in Healthy and Diseased Mice.

Daniele BertoglioJeroen VerhaegheAlan MirandaLeonie WyffelsSigrid StroobantsCelia DominguezIgnacio Munoz-SanjuanMette SkinbjergLongbin LiuSteven Staelens

Published in: Molecular imaging and biology (2020)

Ninety-minute acquisition and the use of SRTM for pharmacokinetic modelling is recommended. [11C]SCH23390 PET imaging demonstrates optimal characteristics for the study of dopamine D1R density in models of psychiatric and neurological disorders as exemplified in the Q175DN mouse model of HD.

Keyphrases

pet imaging
mouse model
mental health
positron emission tomography
high fat diet induced
type diabetes
metabolic syndrome
adipose tissue
blood brain barrier
subarachnoid hemorrhage