No effect of triheptanoin on exercise performance in McArdle disease.
Karen L MadsenPascal LaforêtAstrid E BuchMads G StemmerikChris OttolenghiStéphane N HatemDaniel T Raaschou-PedersenNanna S PoulsenMaria AtencioMarie-Pierre LutonAlexandre CeccaldiRonald G HallerRos QuinlivanFanny MochelJohn VissingPublished in: Annals of clinical and translational neurology (2019)
Despite increased resting plasma malate with triheptanoin, the increase was insufficient to generate a normal TCA turnover during exercise and the treatment has no effect on exercise capacity or oxidative metabolism in patients with McArdle disease.