Hour-1 bundle adherence was associated with reduction of in-hospital mortality among patients with sepsis in Japan.
Yutaka UmemuraToshikazu AbeHiroshi OguraSeitato FujishimaShigeki KushimotoAtsushi ShiraishiDaizoh SaitohToshihiko MayumiYasuhiro OtomoToru HifumiAkiyoshi HagiwaraKiyotsugu TakumaKazuma YamakawaYasukazu ShiinoTaka-Aki NakadaTakehiko TaruiKohji OkamotoJoji KotaniYuichiro SakamotoJunichi SasakiShin-Ichiro ShiraishiRyosuke TsurutaTomohiko MasunoNaoshi TakeyamaNorio YamashitaHiroto IkedaMasashi UeyamaSatoshi GandoPublished in: PloS one (2022)
Completion of the hour-1 bundle was associated with lower in-hospital mortality. Obtaining blood cultures and administering antibiotics within 1 hour may have been the components most contributing to decreased in-hospital mortality.