Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib.

Jung Woo EunJung Hwan YoonHye Ri AhnSeokhwi KimYoung Bae KimSu Bin LimWon ParkTae Wook KangGeum Ok BaekMoon Gyeong YoonJu A SonJi Hyang WeonSoon Sun KimHyo-Jung ChoJae Youn Cheong

Published in: Cancer communications (London, England) (2023)

CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT promotion. Its inhibition represents a promising therapeutic strategy against TKI resistance in HCC. Moreover, plasma SPP1 level before TKI treatment represents a potential biomarker for treatment response prediction.

Keyphrases

tyrosine kinase
advanced non small cell lung cancer
chronic myeloid leukemia
epithelial mesenchymal transition
transcription factor
signaling pathway