Hyperglucagonemia Does Not Explain the β-Cell Hyperresponsiveness and Insulin Resistance in Dysglycemic Youth Compared With Adults: Lessons From the RISE Study.
Steven E KahnKieren J MatherSilva A ArslanianElena BarengoltsThomas A BuchananSonia CaprioDavid A EhrmannTamara S HannonSantica MarcovinaKristen J NadeauKristina M UtzschneiderAnny H XiangSharon L Edelsteinnull nullnull nullPublished in: Diabetes care (2021)
Youth with IGT or recently diagnosed type 2 diabetes (drug naive) have hyperresponsive β-cells and lower insulin sensitivity, but their glucagon concentrations are not increased compared with those in adults. Thus, α-cell dysfunction does not appear to explain the difference in β-cell function and insulin sensitivity in youth versus adults.
Keyphrases
- type diabetes
- mental health
- physical activity
- single cell
- young adults
- cell therapy
- induced apoptosis
- cardiovascular disease
- oxidative stress
- stem cells
- emergency department
- signaling pathway
- adipose tissue
- cell cycle arrest
- hiv infected
- metabolic syndrome
- mesenchymal stem cells
- cell proliferation
- antiretroviral therapy