Independent Causal Effect of Remnant Cholesterol on Atherosclerotic Cardiovascular Outcomes: A Mendelian Randomization Study.
Eliano Pio NavareseDonna F VineSpencer ProctorKlaudyna GrzelakowskaSergio BertiJacek KubicaPaolo RaggiPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
This large-scale Mendelian randomization study showed a robust genetic causal association between RC and cardiovascular outcomes. The effect on CAD and MI is independent of LDL cholesterol. Early screening for RC along with long-term inhibition of RC should be the focus of future therapeutic interventions.
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