Collagen concentration on the facial skin of postmenopausal women after topical treatment with estradiol and genistein: a randomized double-blind controlled trial.
Lidia Aragão SilvaAdriana Aparecida Ferraz CarbonelAndréa Regina Barbosa de MoraesRicardo S SimõesGisela Rodrigues da Silva SassoLívia GoesWinnie NunesManuel Jesus SimõesMarisa Teresinha PatriarcaPublished in: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (2017)
Our data showed an increase in the amount of both type I and type III facial collagen by the end of both treatments. However, the outcomes of the estrogen GI (ER) group were superior to the genistein GII (GEN) group, with statistical significance p < 000.1 Conclusion: Treatment with topical estrogen is superior to genistein, but both have positive impacts on facial skin collagen. Nevertheless, it is still unclear whether prolonged use of genistein and other topical phytoestrogens could produce systemic effects and further research is needed to clarify this question.
Keyphrases
- wound healing
- postmenopausal women
- soft tissue
- estrogen receptor
- double blind
- type iii
- bone mineral density
- clinical trial
- type diabetes
- study protocol
- machine learning
- open label
- body composition
- electronic health record
- skeletal muscle
- smoking cessation
- placebo controlled
- artificial intelligence
- weight loss
- drug induced