Timing of diagnosis of fetal structural abnormalities after the introduction of universal cell-free DNA in the absence of first-trimester anatomical screening.
Francesca BardiAnne Marie BeekhuisMarian Karolien BakkerAyten Elvan-TaşpınarCaterina Maddalena BilardoPublished in: Prenatal diagnosis (2022)
When FTAS is not part of screening paradigms, most fetal anomalies remain undetected until the second trimester or later in pregnancy, including 56% of anomalies "always detectable" in the first trimester.