BKCa participates in E2 inducing endometrial adenocarcinoma by activating MEK/ERK pathway.

Fenfen WangQin ChenGenping HuangXuedong GuoNa LiYang LiBaohua Li

Published in: BMC cancer (2018)

Our results demonstrated that BKCa and the key downstream effectors p-ERK1/2 could be involved in important signaling pathways in initiation and development of endometrial adenocarcinoma and may provide a new therapeutic approach for women with endometrial cancer.

Keyphrases

endometrial cancer
signaling pathway
pi k akt
squamous cell carcinoma
locally advanced
epithelial mesenchymal transition
induced apoptosis
cell proliferation
rectal cancer
radiation therapy