A novel compound EPIC-0412 reverses temozolomide resistance via inhibiting DNA repair/MGMT in glioblastoma.

Jixing ZhaoShixue YangXiaoteng CuiQixue WangEryan YangFei TongBiao HongMenglin XiaoLei XinCan XuYanli TanChun-Sheng Kang

Published in: Neuro-oncology (2022)

This study discovered a small-molecule inhibitor EPIC-0412, which enhanced the chemotherapeutic effect of TMZ by acting on the p21-E2F1 DNA damage repair axis and ATF3-p-p65-MGMT axis, providing evidence for combining epigenetic drugs to increase the sensitization toward TMZ in GBM patients.

Keyphrases

dna repair
dna damage
small molecule
newly diagnosed
end stage renal disease
ejection fraction
oxidative stress
chronic kidney disease
dna methylation
prognostic factors
peritoneal dialysis
gene expression
transcription factor
patient reported outcomes
drug induced