Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection.
Judith M HaissmanAnna K HaugaardSisse R OstrowskiRolf K BergeJohannes R HovMarius TrøseidSusanne Dam NielsenPublished in: BMC infectious diseases (2017)
In contrast to recent studies in HIV-uninfected populations, the present study found no evidence of TMAO-induced platelet hyperreactivity in HIV infected individuals. Microbial translocation and monocyte activation may affect TMAO levels in untreated individuals. Furthermore, the elevated ratios of TMAO/betaine and TMAO/carnitine in cART-treated individuals could possibly suggest a role of cART in TMAO metabolism.
Keyphrases
- hiv infected
- antiretroviral therapy
- cardiovascular disease
- human immunodeficiency virus
- hiv positive
- dendritic cells
- hiv aids
- endothelial cells
- magnetic resonance
- type diabetes
- hepatitis c virus
- microbial community
- peripheral blood
- metabolic syndrome
- computed tomography
- high glucose
- men who have sex with men
- hiv testing
- diabetic rats
- newly diagnosed
- genetic diversity