Efficacy of lysostaphin-coated titanium plates on implant-associated MRSA osteitis in minipigs.
Carina JaekelCeylan D WindolfDan BielerLisa OezelLars F SeilerFelix N LakomekChristoph BeyersdorfJann MertensAndrea SteuweJoachim WindolfJan P GrassmannPublished in: European journal of trauma and emergency surgery : official publication of the European Trauma Society (2024)
This study confirms the minipig model for examining IAI. Furthermore, coating of plates using lysostaphin could be a promising tool in the therapeutic strategies of IAI. Future studies should focus on coating technology of implants and on translation into a clinical model.