Visualizing Cancer-Originating Acetate Uptake Through MCT1 in Reactive Astrocytes in the Glioblastoma Tumor Microenvironment.
Dongwoo KimHae Young KoJee-In ChungYongmin Mason ParkSangwon LeeSeon Yoo KimJisu KimJoong-Hyun ChunKyung-Seok HanMisu LeeYeon Ha JuSun Jun ParkKi Duk ParkMin-Ho NamSe-Hoon KimJin-Kyoung ShimYoungjoo ParkHyunkeong LimJaekyung ParkHyunjin KimSuhyun KimUiyeol ParkHoon RyuSo Yun LeeSunghyouk ParkSeok-Gu KangJong Hee ChangJustin Daho LeeMijin YunPublished in: Neuro-oncology (2023)
Our results highlight the role of acetate derived from glioblastoma cells in inducing reactive astrogliosis and underscore the potential value of 11C-acetate PET as an imaging technique for detecting reactive astrogliosis, offering important implications for the diagnosis and treatment of glioblastomas.