Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression.

Lei DuCong-Rong LiQi-Feng HeXiao-Hua LiLin-Fei YangYuan ZouZhi-Xia YangDong ZhangXiao-Wei Xing

Published in: Molecular medicine (Cambridge, Mass.) (2020)

Proper KBTBD8 level is essential for the healthy growth of ovarian somatic cells, such as ovarian epithelial cells. Excessive KBTBD8 might be a significant impetus for EOC progression. KBTBD8 reduction greatly inhibits EOC proliferation and migration.

Keyphrases

induced apoptosis
cell proliferation
signaling pathway
weight gain
endoplasmic reticulum stress
body mass index
oxidative stress