Matrix metalloproteinase-8 regulates dendritic cell tolerance in late polymicrobial sepsis via the nuclear factor kappa-B p65/β-catenin pathway.

Zhong-Qiu LuChen ZhangLin-Jun ZhaoWei DongLiang LvYang LuXiao-Yan ChenJie ZhangXin-Yong LiuZhong XiaoLong-Wang ChenYong-Ming YaoGuang-Ju Zhao

Published in: Burns & trauma (2024)

Increased MMP8 levels in septic DCs might serve as a negative feedback loop, thereby suppressing the proinflammatory response and inducing DC tolerance.

Keyphrases

nuclear factor
dendritic cells
toll like receptor
acute kidney injury
immune response
regulatory t cells
intensive care unit
septic shock
transcription factor
inflammatory response