Low-dose sumatriptan improves the outcome of acute mesenteric ischemia in rats via downregulating kynurenine.

Moein AlaMohammad Reza Fallahpour KhoshdelRazieh Mohammad JafariMehrdokht SadrkhanlooSepideh GoudarziMeisam Asl SoleimaniAhmad Reza Dehpour

Published in: Pharmacological reports : PR (2023)

This study demonstrated that sumatriptan has protective effects against mesenteric ischemia and the kynurenine inhibition is potentially involved in this process. Therefore, it can be assumed that sumatriptan has the potential to be repurposed as a treatment for acute mesenteric ischemia.

Keyphrases

liver failure
low dose
respiratory failure
drug induced
aortic dissection
high dose
hepatitis b virus
extracorporeal membrane oxygenation
human health
risk assessment
replacement therapy