A systematic review and meta-analysis on the association between ICSI and chromosome abnormalities.

Sine BerntsenHannele LaivuoriNina la Cour FreieslebenAnne LoftViveca Söderström-AnttilaNan B OldereidLiv Bente RomundstadÅsa MagnussonMax PetzoldChristina BerghAnja Pinborg

Published in: Human reproduction update (2022)

This review provides an extensive overview of the existing evidence on the relationship between ICSI and chromosome abnormalities in the offspring. We highlight the need for well-designed large, prospective, controlled studies with systematic cytogenetic testing. Existing data are limited and, in many cases, marred by critical levels of bias.

Keyphrases

copy number
pregnancy outcomes
high fat diet
electronic health record
big data
case control
machine learning
metabolic syndrome
data analysis
adipose tissue
skeletal muscle
genome wide