Computational modeling of drug response identifies mutant-specific constraints for dosing panRAF and MEK inhibitors in melanoma.

Andrew GoetzFrances ShanahanLogan BrooksEva LinRana MroueDarlene Dela CruzThomas HunsakerBartosz CzechPurushottam DixitUdi SegalScott MartinScott A FosterLuca Gerosa

Published in: bioRxiv : the preprint server for biology (2024)

Leveraging pre-clinical data and computational modeling, our approach proposes dosage strategies that can optimize synergy in drug combinations, while also bringing forth the real-world challenges of staying within a precise dose range.

Keyphrases

electronic health record
adverse drug
genome wide
big data
gene expression
drug induced
cell proliferation
pi k akt
machine learning
signaling pathway
wild type
data analysis