Personality predictors of dementia diagnosis and neuropathological burden: An individual participant data meta-analysis.
Emorie D BeckTomiko YonedaBryan D JamesDavid A BennettJason HassenstabMindy J KatzRichard B LiptonJohn MorrisDaniel K MroczekEileen K GrahamPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
N(+), C(-), E(-), PA(-), and NA(+) were associated with incident diagnosis. Results were consistent despite self-report versus clinical diagnosis of dementia. Psychological factors were not associated with neuropathology at autopsy. Individuals with higher conscientiousness and no diagnosis had less neuropathology. High C individuals may withstand neuropathology for longer before death.