Nonreportable rates and cell-free DNA profiles in noninvasive prenatal testing among women with heparin treatment.
Noriyuki NakamuraAiko SasakiMasashi MikamiMiyuki NishiyamaRina AkaishiSeiji WadaNobuaki OzawaHaruhiko SagoPublished in: Prenatal diagnosis (2020)
Heparin use increased the nonreportable rate of NIPT results by borderline Z-scores, possibly caused by the increased proportions of shorter and GC-rich cfDNA fragments. This information will be helpful for prenatal genetic counseling for patients requiring heparin treatment.
Keyphrases
- venous thromboembolism
- pregnant women
- end stage renal disease
- growth factor
- newly diagnosed
- ejection fraction
- chronic kidney disease
- genome wide
- prognostic factors
- combination therapy
- high resolution
- mass spectrometry
- smoking cessation
- social media
- men who have sex with men
- hiv testing
- gas chromatography
- tandem mass spectrometry