Frizzled 4 regulates ventral blood vessel remodeling in the zebrafish retina.

Lucia CaceresSergey V PrykhozhijElizabeth CairnsHarald GjerdeNicole M DuffKeon CollettMike NgoGheyath K NasrallahChristopher R McMasterMatthew LitvakJohane M RobitailleJason N Berman

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2019)

We have generated a visually impaired zebrafish FEVR model exhibiting abnormal retinal vasculature. These fish provide a tractable system for studying vascular biology in retinovascular disorders, and demonstrate the feasibility of using zebrafish for evaluating future FEVR genes identified in humans.

Keyphrases

diabetic retinopathy
optic nerve
optical coherence tomography
genome wide
current status
gene expression
deep brain stimulation
spinal cord injury
transcription factor
dna methylation
prefrontal cortex
bioinformatics analysis
genome wide analysis