Phenotypical Flexibility of the EGFRvIII-Positive Glioblastoma Cell Line and the Multidirectional Influence of TGFβ and EGF on These Cells-EGFRvIII Appears as a Weak Oncogene.

Aneta WlodarczykCezary TrędaAdrianna Rutkowska Dagmara Grot Weronika DobrewaAmelia KierasińskaMarta WęgierskaTomasz WasiakTadeusz StrózikPiotr RieskeEwelina Stoczyńska-Fidelus

Published in: International journal of molecular sciences (2022)

The roles of TGFβ and EGF in the EGFRvIII context remain unclear. EGFRvIII appears as a weak oncogene and not a marker of GSC (glioma stem cells). Hence, it may not be a proper target for CAR-T (chimeric antigen receptor T cells).

Keyphrases

stem cells
transforming growth factor
induced apoptosis
growth factor
cell cycle arrest
epithelial mesenchymal transition
endoplasmic reticulum stress
oxidative stress
signaling pathway