Molecularly imprinted and cladded polymers for constructing a portable plasmonic immunoassay for peptides in biofluids.
Zhanchen GuoQi ZhangRongrong XingZhen LiuPublished in: Chemical communications (Cambridge, England) (2023)
Using two molecularly imprinted and cladded polymers (cMIPs), an inexpensive, fast and portable plasmonic immuno-sandwich assay (PISA) was rationally developed for high-specificity and ultra-sensitive detection of C-peptide in urine. The dual cMIPs-based PISA allowed healthy individuals to be distinguished from diabetes patients and exhibited several significant merits over existing immunoassays, holding great promise in clinical diagnosis.
Keyphrases
- molecularly imprinted
- sensitive detection
- solid phase extraction
- end stage renal disease
- type diabetes
- quantum dots
- ejection fraction
- newly diagnosed
- cardiovascular disease
- chronic kidney disease
- single molecule
- peritoneal dialysis
- prognostic factors
- high resolution
- high throughput
- label free
- glycemic control
- energy transfer
- machine learning
- adipose tissue
- amino acid
- skeletal muscle
- patient reported outcomes
- patient reported
- structural basis