The novel MFS efflux pump SxtP, regulated by the LysR-type transcriptional activator SxtR, is involved in the susceptibility to sulfamethoxazole/trimethoprim (SXT) and the pathogenesis of Acinetobacter baumannii .
Marc GaonaJordi CorralSusana CampoyJordi BarbéMaría Pérez VarelaJesús ArandaPublished in: Antimicrobial agents and chemotherapy (2024)
Acinetobacter baumannii is a notorious opportunistic pathogen responsible for healthcare-associated infections worldwide. Efflux pumps play crucial roles in mediating antimicrobial resistance, motility, and virulence. In this study, we present the identification and characterization of the new A. baumannii efflux pump SxtP belonging to the MFS superfamily ( m ajor f acilitator s uperfamily), along with its associated activator L ysR - type t ranscriptional r egulator (LTTR) SxtR, demonstrating their roles in sulfamethoxazole/trimethoprim (also known as co-trimoxazole or SXT) resistance, surface-associated motility and virulence.
Keyphrases
- acinetobacter baumannii
- antimicrobial resistance
- pseudomonas aeruginosa
- biofilm formation
- multidrug resistant
- drug resistant
- healthcare
- nuclear factor
- cystic fibrosis
- candida albicans
- escherichia coli
- antibiotic resistance genes
- staphylococcus aureus
- gene expression
- transcription factor
- inflammatory response
- health information
- microbial community
- oxidative stress
- heat stress
- social media