Metformin Radiosensitizing Effect on Hypoxic Oral Squamous Cell Carcinoma Cells by GAPDH and TAGLN2.

Eloá Mangabeira SantosLucyana Conceição FariasTalita Antunes GuimarãesEliane Macedo Sobrinho SantosSabrina Ferreira de JesusMarcela Gonçalves de SouzaPericles Crisostomo de SouzaLuiza SantiagoMarcos Flávio Silveira Vasconcelos D'AngeloAlfredo Maurício Batista De-PaulaSérgio Henrique Sousa SantosAndre Luiz Sena Guimaraes

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2024)

This study suggests that metformin can enhance radiosensitivity in hypoxic cells, operating through modulation of GAPDH and TAGLN2. Furthermore, metformin effectively reduces mutated p53 levels in radiated cells under hypoxic conditions.

Keyphrases

induced apoptosis
cell cycle arrest
squamous cell
endoplasmic reticulum stress
oxidative stress