Biological therapies in patients with liver disease: are they really lifesavers?

: Biological therapies have changed the natural history of main autoimmune diseases and solid cancers. Compared to other organs and disease settings, the liver lags behind in biologics and their applications. The development of novel diagnostic and therapeutic strategies based on the immunological and antigenic characteristics of the hepato-biliary system could reduce mortality and transplant rates linked to chronic liver diseases.