BUB1B monoallelic germline variants contribute to prostate cancer predisposition by triggering chromosomal instability.

Maria P SilvaLuísa T FerreiraNatércia F BrásLurdes TorresAndreia BrandãoManuela PinheiroMarta CardosoAdriana ResendeJoana VieiraCarlos PalmeiraGabriela MartinsMiguel SilvaCarla PintoAna PeixotoJoão SilvaRui HenriqueSofia MaiaHelder MaiatoManuel R TeixeiraPaula Paulo

Published in: Journal of biomedical science (2024)

Our study shows that different BUB1B variants may uncover a trigger for CIN-driven carcinogenesis, supporting the role of BUB1B as a (pan)-cancer predisposing gene with potential impact on genetic counseling and treatment decision-making.

Keyphrases

copy number
prostate cancer
genome wide
decision making
papillary thyroid
dna methylation
radical prostatectomy
dna repair
squamous cell carcinoma
gene expression
human health
young adults
dna damage
hepatitis c virus
replacement therapy
climate change
hiv infected
genome wide identification