Mismatch repair protein loss in breast cancer: clinicopathological associations in a large British Columbia cohort.

Angela S ChengSamuel C Y LeungDongxia GaoSamantha BuruguMeenakshi AnuragMatthew J EllisTorsten O Nielsen

Published in: Breast cancer research and treatment (2019)

Overall, this study supports the concept that breast cancer patients with MMR deficiency as assessed by immunohistochemistry may be good candidates for alternative treatment approaches such as immune checkpoint or CDK4 inhibitors.

Keyphrases

cell cycle
replacement therapy
small molecule
amino acid
cell proliferation
binding protein
smoking cessation