Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases.

Jason A ChenZhongbo ChenHyejung WonAlden Y HuangJennifer K LoweKevin WojtaJennifer S YokoyamaGilbert BensimonP Nigel LeighChristine PayanAleksey ShatunovAshley R JonesCathryn M LewisPanagiotis DeloukasPhilippe AmouyelChristophe TzourioJean-Francois DartiguesAlbert LudolphAdam L BoxerJeff M BronsteinAmmar Al-ChalabiDaniel H GeschwindGiovanni Coppola

Published in: Molecular neurodegeneration (2018)

In total, we identified 6 additional significant or suggestive SNP associations with PSP, and discovered genetic overlap with other neurodegenerative diseases. These findings clarify the pathogenesis and genetic architecture of PSP.

Keyphrases

genome wide
genome wide association study
dna methylation
copy number
multiple sclerosis
gene expression