Somatostatin receptor saturation after administration of high peptide amounts of [ 177 Lu]Lu-HA-DOTATATE: when enough is enough.
Hinke SiebingaChayenne H A M VeermanBerlinda Jantina de Wit-van der VeenMarcel P M StokkelJeroen J M A HendrikxElse A AalbersbergPublished in: EJNMMI research (2022)
Lu]Lu-HA-DOTATATE, with receptor saturation in spleen for high and standard peptide amounts, while tumor and kidney receptor saturation occur only with high administered peptide amounts. A high peptide amount (~ 350 µg) is not recommended for standard-dose PRRT and standard amounts (~ 200 µg) seem more suitable to achieve optimal tumor accumulation with limited organ uptake.
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