A kinetic model for positive allosteric modulator (PAM)-antagonists for the type 1 cannabinoid receptor (CB 1 ).

Liang YangXiao Zhu David B FinlayHayley GreenMichelle GlassStephen B Duffull

Published in: British journal of pharmacology (2023)

allosteric modulation was developed. However, a standard ternary complex model was not sufficient to capture the data and a hypothetical transitional state was required to describe the allosteric modulation properties of ORG.

Keyphrases

small molecule
electronic health record
machine learning
binding protein
artificial intelligence