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Long-Term Accumulation, Biological Effects and Toxicity of BSA-Coated Gold Nanoparticles in the Mouse Liver, Spleen, and Kidneys.

Kristina JakicMichal SelcFilip RázgaVeronika NemethovaPetra MazancovaFilip HavelMichal SramekMonika ZarskaJan ProskaVlasta MasanovaIveta UhnakovaPeter MakovickyMarta NovotovaVit VykoukalAndrea Babelova
Published in: International journal of nanomedicine (2024)
Our data suggest, that although AuNPs belong to the safest nanomaterial platforms nowadays, due to their slow tissue elimination leading to long-term accumulation in the biological systems, they may induce toxic responses in the vital organs, and so understanding of their long-term biological impact is important to consider their potential therapeutic applications.
Keyphrases
  • gold nanoparticles
  • oxidative stress
  • machine learning