Construction of Chiral Tetraorganosilicons by Tandem Desymmetrization of Silacyclobutanes/Intermolecular Dehydrogenative Silylation.

Qing-Wei ZhangKun AnLi-Chuan LiuQi ZhangHuifang GuoWei He

Published in: Angewandte Chemie (International ed. in English) (2016)

We report a method to construct chiral tetraorganosilicons by tandem silacyclobutane (SCB) desymmetrization-dehydrogenative silylations. A wide array of dibenzosiloles with stereogenic quaternary silicon centers were obtained in good yields and enantioselectivities up to 93 % ee. Chiral TMS-segphos was found to be a superior ligand in terms of reactivity and enantioselectivity.

Keyphrases

capillary electrophoresis
ionic liquid
mass spectrometry
transcranial magnetic stimulation
high throughput
high frequency
high density
quantum dots