Synergy between Mecillinam and Ceftazidime/Avibactam or Avibactam against Multi-Drug-Resistant Carbapenemase-Producing Escherichia coli and Klebsiella pneumoniae .
Karoline Knudsen ListMette KolpenKasper Nørskov KraghGodefroid CharbonStine RadmerFrank HansenAnders Løbner-OlesenNiels Frimodt-MøllerFrederik Boetius HertzPublished in: Antibiotics (Basel, Switzerland) (2022)
Mecillinam in combination with avibactam or ceftazidime/avibactam has a notable effect on most types of CPEs, both in vitro and in vivo. The mecillinam/avibactam combination treatment could be a new efficient antibiotic treatment against multi-drug-resistant carbapenemase-producing Gram-negative pathogens.