Vaccination with a Leishmania infantum HSP70-II null mutant confers long-term protective immunity against Leishmania major infection in two mice models.

José Carlos SolanaLaura RamírezLaura CorvoCamila Indiani de OliveiraManoel Barral-NettoJosé María RequenaSalvador IborraManuel Soto

Published in: PLoS neglected tropical diseases (2017)

Inoculation of the LiΔHSP70-II attenuated line activates mammalian immune system for inducing moderate pro-inflammatory responses. These responses are able to confer long-term protection in mice against the infection of L. major virulent parasites.

Keyphrases

heat shock protein
high fat diet induced
wild type
heat shock
heat stress
type diabetes
insulin resistance
oxidative stress
skeletal muscle
solid state