Coronary microevaginations characterize culprit plaques and their inflammatory microenvironment in a subtype of acute coronary syndrome with intact fibrous cap: results from the prospective translational OPTICO-ACS study.
Claudio SeppeltYoussef S AbdelwahedDenitsa MetevaGregor NellesBarbara E StähliAslihan ErbayNicolle KränkelLara SieronskiCarsten SkurkArash HaghikiaDavid SinningHenryk DregerFabian KnebelTobias D TrippelMaximilian KrisperTeresa GerhardtHimanshu RaiJens KlotscheMichael JonerUlf LandmesserDavid M LeistnerPublished in: European heart journal. Cardiovascular Imaging (2023)
This study provides novel evidence for a pathophysiological involvement of CME in the development of IFC-ACS and provides first evidence for a distinct pathophysiological pathway for IFC-ICB, driven by CME-derived flow disturbances and inflammatory activation involving the innate immune system.