Maternal sevoflurane exposure induces temporary defects in interkinetic nuclear migration of radial glial progenitors in the fetal cerebral cortex through the Notch signalling pathway.
Ming JiangTianxiang TangXinyue LiangJuchen LiYue QiuShiwen LiuShan BianYunli XieFang FangJing CangPublished in: Cell proliferation (2021)
Maternal sevoflurane exposure during neurogenic period temporarily induced abnormal INM of RGPs by targeting the Notch signalling pathway without inducing long-term effects on RGP progeny cell fate or offspring cognitive behaviours. More importantly, the defects of INM in hESC-derived cerebral organoids provide a novel insight into the effects of general anaesthesia on human brain development.
Keyphrases
- cell fate
- subarachnoid hemorrhage
- birth weight
- pregnancy outcomes
- cell proliferation
- spinal cord injury
- high glucose
- high fat diet
- cerebral ischemia
- functional connectivity
- neuropathic pain
- brain injury
- drug induced
- pregnant women
- skeletal muscle
- blood brain barrier
- body mass index
- spinal cord
- physical activity
- endothelial cells
- insulin resistance
- preterm birth