Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity.
Vanessa YuFiona YongAngellica MartaSanjay KhadayateAdrien OsakweSupriyo BhattacharyaSneha S VarghesePauline ChabosseauSayed M TabibiKeran ChenEleni GeorgiadouNazia ParveenMara SuleimanZoe StamoulisLorella MarselliCarmela De LucaMarta TesiGiada OstinelliLuis Delgadillo-SilvaXiwei WuYuki HatanakaAlex MontoyaJames ElliottBhavik PatelNikita DemchenkoChad WhildingPetra HajkovaPavel ShliahaHolger KramerYusuf AliPiero MarchettiRobert SladekSangeeta DhawanDominic J WithersGuy A RutterSteven J MillershipPublished in: bioRxiv : the preprint server for biology (2023)
cells are likelier to belong to the population of 'follower', rather than 'hub' cells, consistent with a role in insulin production rather than glucose detection How might this impact on clinical practice in the foreseeable future?- Epigenome-modifying compounds may provide a way of enhancing beta cell function and the ensemble behaviour of the islet to stimulate insulin secretion.
Keyphrases
- induced apoptosis
- dna methylation
- cell cycle arrest
- clinical practice
- single cell
- type diabetes
- endoplasmic reticulum stress
- stem cells
- signaling pathway
- oxidative stress
- genome wide
- gene expression
- cell proliferation
- cell therapy
- blood pressure
- blood glucose
- machine learning
- adipose tissue
- mesenchymal stem cells
- deep learning
- real time pcr
- monte carlo