Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson's disease.

Yan-Fang HouChang ShanSi-Yue ZhuangQian-Qian ZhuangArijit GhoshKe-Cheng ZhuXiao-Ke KongShu-Min WangYan-Ling GongYu-Ying YangBei TaoLi-Hao SunHong-Yan ZhaoXing-Zhi GuoWei-Qing WangGuang NingYan-Yun GuSheng-Tian LiJian-Min Liu

Published in: Microbiome (2021)

Together, our results demonstrate that OCN ameliorates motor deficits and dopaminergic neuronal loss in PD mice, modulating gut microbiome and increasing propionate level might be an underlying mechanism responsible for the neuroprotective effects of OCN on PD, and the FFAR3, expressed in enteric nervous system, might be the main action site of propionate. Video abstract.

Keyphrases

mouse model
cerebral ischemia
traumatic brain injury
subarachnoid hemorrhage
signaling pathway
blood brain barrier
high fat diet induced
insulin resistance
metabolic syndrome