Polarization of human gingival fibroblasts by Th1-, Th2-, Th17-, and Treg-derived cytokines.

Da Young HaJae-Suk JungGeum Hee ChoiSuk Ji

Published in: Journal of periodontal research (2022)

These results show that Th cytokines can polarize GFs into cells with functionally distinct features: immune-activating but tissue-destructive GF(IFN-γ), tissue-reparative, and immune-inhibiting GF(IL-4), highly pro-inflammatory GF(IL-17), and potent tissue-reparative GF(TGF-β).

Keyphrases

signaling pathway
induced apoptosis
immune response
transforming growth factor
cell death
endoplasmic reticulum stress
cell proliferation
induced pluripotent stem cells