Blockade of glucose-6-phosphate dehydrogenase induces immunogenic cell death and accelerates immunotherapy.

Motoki NakamuraTetsuya MagaraMaki YoshimitsuShinji KanoHiroshi KatoKeisuke YokotaKatsuhiro OkudaAkimichi Morita

Published in: Journal for immunotherapy of cancer (2024)

G6PD inhibition is a potent therapeutic strategy that triggers immunogenic cell death in tumors, significantly augmenting the efficacy of immunotherapies.

Keyphrases

cell death
cell cycle arrest
anti inflammatory
blood pressure
glycemic control