Regiospecific methylation of all the hydroxyls in (+)-catechin by a stepwise differentiation strategy.

Regiospecific methylation of the phenolic and aliphatic hydroxyls was systematically achieved under mild conditions. Preparation of all the individual methylated (+)-catechins was accomplished with a greener methylation reagent: nonvolatile Meerwein salt. This work laid a solid foundation for preparation of diverse O-methylated catechins for bioactivity studies. © 2019 Society of Chemical Industry.